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KMID : 1149220040120020155
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Korean Journal of Oriental Medical Prescription
2004 Volume.12 No. 2 p.155 ~ p.162
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Protective effect of Cynomorii Herba extract on H2O2-induced cytotoxicity
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Oh Myung-Sook
Kim Do-Rim
Yang Woong-Mo
Chang Mun-Seog
Park Soo-Yeon
Kang Soon-Ah
Park Seong-Kyu
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Abstract
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The purpose of this study is to examine the protective effect of Cynomorii herba on H2O2-induced cytotoxicity in male germ cells. The effects were studied by a modified MTT assay. Hydrogen peroxide significantly induced cytotoxicity in GC-1 spg cells, and co-treatment or pre-treatment of Cynomorii herba extract has reduced the cytotoxicity in a dose dependant manner. These results suggest that Cynomorii herba extract increases the survival rate of GC-1 spg cells through the antioxidant effect against H2O2-induced cytotoxicity.
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KEYWORD
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Cynomorii herba, MTT assay, Hydrogen peroxide(H2O2), cytotoxicity, GC-1 spg cells
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